Kaposi sarcoma is a skin cancer that causes multiple flat pink, red, or purple patches or bumps on the skin. It is caused by human herpesvirus type 8 infection.
One or a few spots may appear on the toes or a leg, or spots may appear anywhere on the body or in the mouth or genital areas, then spread to other areas, including internal organs.
Although this cancer can often be identified by sight, doctors usually also do a biopsy.
Spots may be removed or treated with radiation therapy, but if the cancer is aggressive, treatment includes chemotherapy or interferon alfa.
There are many types of human herpesviruses. One of them, type 8, can cause Kaposi sarcoma, particularly in people with a weakened immune system.
There are 5 types of Kaposi sarcoma. The types occur in several distinct groups of people and act differently in each group. It occurs in the following:
Classic Kaposi sarcoma: This type affects older men, usually of Mediterranean, Eastern European, or Ashkenazi Jewish heritage.
Endemic Kaposi sarcoma: Endemic means this cancer occurs regularly in a certain place. It affects children and young adults from certain parts of Africa.
Iatrogenic Kaposi sarcoma: This type affects people whose immune system is weakened by medications that suppress the immune system (immunosuppressants) given after organ transplantation.
AIDS-associated Kaposi sarcoma (epidemic Kaposi sarcoma): This type affects people with AIDS.
Non-epidemic: This type has been increasingly recognized and occurs in men who are HIV-negative and who have sex with men.
Dalili za Sarikoma ya Kaposi
Kaposi sarcoma usually appears as purple, pink, brown, or red spots or bumps on the skin. The cancer may grow to several inches or more as blue-violet to black, flat or slightly raised areas. Swelling may be present. Sometimes the cancer grows deeper into soft tissues and invades bone.
Cancer of mucosal surfaces, such as in the mouth, are blue to violet in color. In the digestive tract, the cancer can sometimes bleed excessively but usually causes no symptoms.
Saratani ya Kaposi ya aina ya kawaida
Men over age 60 with the classic type may develop several additional spots on the legs, but the cancer rarely spreads to other parts of the body and is almost never fatal.
In the 4 other types of Kaposi sarcoma, the cancer may be more aggressive. Similar-appearing spots develop, but they are often multiple and may occur anywhere on the body.
Saratani ya Kaposi inayoegemea - AIDS
Within several months, people with the AIDS-associated type develop spots that spread to other parts of the body, such as the face and torso, often including the mouth, where they cause pain with eating.
The spots may also develop in lymph nodes and internal organs, especially the digestive tract, where they can cause internal bleeding that leads to blood in the stool. Sometimes Kaposi sarcoma is the first symptom of AIDS.
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Iatrogeniki Kaposi sakoma (sakoma ya Kaposi inayopunguza kinga)
This type typically develops several years after organ transplantation. It can be severe, and spots may rapidly develop.
Saratani ya Kaposi ya Asili
In children, the endemic type usually involves the lymph nodes. The children may or may not have spots on the skin. The disease is usually sudden, severe, and fatal.
In adults, the endemic type tends to cause slow-growing spots and patches on the skin similar to those of the classic type. The cancer rarely spreads to other parts of the body and is not likely to be fatal.
Kaposi sakoma isiyo ya janga
This recently described type typically manifests with individual spots similar to classic Kaposi sarcoma, but it occurs specifically in men who are HIV-negative and who have sex with men. The severity of this type is still being studied.
Utambuzi wa Sarikoma ya Kaposi
Punch biopsy
Doctors diagnose Kaposi sarcoma by doing a punch biopsy, in which a small piece of skin is removed for examination under a microscope, is usually done to confirm the diagnosis of Kaposi sarcoma.
For people with AIDS or immunosuppression, doctors do other tests to determine where the cancer has spread. Doctors usually do a computed tomography (CT) scan of the chest and the abdomen and do other tests depending on the person's symptoms.
Matibabu ya Sarikoma ya Kaposi
For people with one or two spots, various removal methods
For people with many spots, many affected areas, or affected lymph nodes, radiation therapy and chemotherapy
For the AIDS-associated type, antiretroviral medications and removal methods or antiretroviral medications and chemotherapy
Treatment varies depending on the type of sarcoma.
Saratani ya Kaposi ya aina ya kawaida
Older men with slow-growing classic Kaposi sarcoma in one or two spots may have the tumors removed surgically, with extreme cold (cryosurgery), or with an electrical current (electrocoagulation). Imiquimod cream, alitretinoin gel, or injections of vinblastine or interferon alfa into the spots may also be used to remove the spots. Some people with very few spots and no other symptoms may choose to receive no treatment unless the condition spreads.
People who have many spots, many affected areas, or affected lymph nodes receive radiation therapy and chemotherapy. Kaposi sarcoma commonly returns and is difficult to completely cure.
People who have a more aggressive form that affects internal organs, but whose immune system is normal, often respond to interferon alfa or, more often, chemotherapy given by vein.
Iatrogenic Kaposi sakoma
In people taking immunosuppressant medications, the tumors sometimes disappear when immunosuppressant medications are stopped. However, if these medications must be continued because of the person’s underlying condition, the dose is reduced. If the dose of immunosuppressants cannot be reduced, surgery, chemotherapy, and radiation therapy are used. People may also be given an immunosuppressant medication called sirolimus. These treatment methods are less successful than in people with a healthy immune system.
Saratani ya Kaposi inayoegemea - AIDS
In people with AIDS, treatment with chemotherapy and radiation has not been very successful. However, intensive treatment with antiretroviral therapy (ART) helps. Some people who have the AIDS-associated type need only ART and the removal methods noted above. Other people who have the AIDS-associated type may need chemotherapy (such as doxorubicin or paclitaxel) by vein or other medications (such as vinblastine or pomalidomide) in addition to ART. In general, treating Kaposi sarcoma does not prolong the lives of most people with AIDS.
Saratani ya Kaposi ya Asili
The endemic type is difficult to treat. Doctors typically make sure people are comfortable and free of pain and that their symptoms are fully treated.
Kaposi sakoma isiyo ya janga
Spots that appear in people who have this type of sarcoma are treated the same way as in classic Kaposi sarcoma.
Maelezo Zaidi
The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
American Cancer Society: Kaposi Sarcoma: Information about Kaposi sarcoma, including detection, prevention, treatment options, and other resources
