Some Types of Glycogen Storage Diseases
Name* | Affected Organs, Tissues, or Cells | Symptoms |
|---|---|---|
GSD 0 | Liver or muscle | Episodes of low blood sugar levels (hypoglycemia) during fasting if the liver is affected |
GSD I (von Gierke disease) | ||
Type Ia | Liver and kidney | Enlarged liver and kidney, slowed growth, very low blood sugar levels, and abnormally high levels of acid, fats, and uric acid in blood |
Type Ib | Liver and white blood cells | Same as in von Gierke disease Low white blood cell count, recurring infections, and inflammatory bowel disease |
GSD II (Pompe disease) | All organs | Enlarged liver and heart and muscle weakness |
GSD III (Cori disease, Forbes disease) | Liver, muscle, and heart | Enlarged liver or cirrhosis, low blood sugar levels, muscle damage, heart damage, and weak bones in some people |
GSD IV (Andersen disease) | Liver, muscle, and most tissues | Cirrhosis, muscle damage, and delayed growth and development |
GSD V (McArdle disease) | Muscle | Muscle cramps or weakness during physical activity |
GSD VI (Hers disease) | Liver | Enlarged liver Episodes of low blood sugar during fasting Often no symptoms |
GSD VII (Tarui disease) | Skeletal muscle and red blood cells | Muscle cramps during physical activity and red blood cell destruction (hemolysis) |
GSD VIII/IX | Liver Kidneys | Enlarged liver Low blood sugar Kidney problems Short stature Rickets, weak bones |
* There are many different glycogen storage diseases. Each is identified by a Roman numeral. | ||
GSD = glycogen storage disease. | ||