Загальні відомості про порушення пігментації

ЗаShinjita Das, MD MPH, Massachusetts General Hospital
Переглянуто/перевірено жовт. 2022

    Melanin is the brownish pigment responsible for the color of skin, hair, and the iris of the eyes. It is produced by melanocytes. Most people have similar numbers of melanocytes, and the wide range of color shades of human skin is due to the amount of melanin that is produced rather than the number of melanocytes. There are different subtypes of melanin, the main ones in the skin being

    • Eumelanin (brown and black types)

    • Pheomelanin, which has a reddish hue

    Ultraviolet radiation, as in sunlight, stimulates melanin production, as do a number of pathologic processes. Other factors can interfere with melanin production.

    Pigmentation disorders involve hypopigmentation, depigmentation, or hyperpigmentation. Areas may be focal or diffuse.

    In hypopigmentation, pigment is decreased, whereas in depigmentation, pigment is completely lost, leaving white skin.

    Focal hypopigmentation is most commonly a consequence of

    Focal hypopigmentation or depigmentation is also a feature of vitiligo (which may involve large areas of skin), leprosy, nutritional deficiencies (kwashiorkor), genetic conditions (eg, tuberous sclerosis, piebaldism, Waardenburg syndrome), morphea (localized scleroderma, in which skin is usually sclerotic), lichen sclerosus, pityriasis versicolor (or tinea versicolor), idiopathic guttate hypomelanosis, progressive macular hypomelanosis, postinflammatory hypopigmentation, and pityriasis alba.

    Morphea
    Сховати деталі
    This image shows multiple sclerotic areas on the trunk typical of morphea.
    Image courtesy of Karen McKoy, MD.

    Diffuse hypopigmentation is most often caused by

    Hyperpigmentation typically occurs after inflammation resulting from various causes. This postinflammatory hyperpigmentation is usually focal in distribution. Hyperpigmentation may also be caused by a systemic disorder, drug, or cancer; in such cases, distribution is usually more diffuse.