Melatonin

Standard dosage is not established and ranges from 0.5 to 5 mg orally taken 1 hour before usual bedtime on the day of travel and 2 to 4 nights after arrival.

1-2).

345).

6). 

7).

8).

9).

10

11).

(See also table Some Possible Dietary Supplement–Drug Interactions.)

1. 1. Melatonin for jet lag. Drug Ther Bull 58(2):21-24, 2020. doi: 10.1136/dtb.2019.000074

2. 2. Buscemi N, Vandermeer B, Pandya R, et alEvid Rep Technol Assess (Summ) (108):1-7, 2004. doi:10.1037/e439412005-001

3. 3. Ferracioli-Oda E, Qawasmi A, Bloch MHPLoS One 8(5):e63773, 2013. doi: 10.1371/journal.pone.0063773

4. 4. Auld F, Maschauer EL, Morrison I, et alSleep Med Rev 34:10-22, 2017. doi: 10.1016/j.smrv.2016.06.005

5. 5. Li T, Jiang S, Han M, et alFront Neuroendocrinol 52:22-28, 2019. doi: 10.1016/j.yfrne.2018.06.004

6. 6. Liira J, Verbeek JH, Costa G, et al. Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Cochrane Database Syst Rev (8):CD009776, 2014. doi:10.1002/14651858.CD009776.pub2

7. 7. McDonagh MS, Holmes R, Hsu F: Pharmacologic treatments for sleep disorders in children: a systematic review. J Child Neurol 34(5):237-247, 2019. doi: 10.1177/0883073818821030

8. 8. Hansen MV, Halladin NL, Rosenberg J, Gögenur I, Møller AMCochrane Database Syst Rev (4):CD009861, 2015. doi:10.1002/14651858.CD009861.pub2

9. 9. Erland LA, Saxena PKJ Clin Sleep Med 13(2):275-281, 2017. doi:10.5664/jcsm.6462

10. 10. Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 11(10):1199-1236, 2015 doi:10.5664/jcsm.5100

11. 11. Lelak K, Vohra V, Neuman MI, et alMMWR Morb Mortal Wkly Rep 71(22):725-729, 2022. doi:10.15585/mmwr.mm7122a1

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

1. National Institutes of Health (NIH), National Center for Complementary and Integrative Health: