Copy Link

PPT CV

PPT MVM

PPT PV

citation

Reddit

Quora

Facebook

WhatsApp

Telegram

snapchat

messenger

Pinterest

Professional

Special Subjects

Dietary Supplements

Glucosamine

Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada) — dedicated to using leading-edge
science to save and improve lives around the world. Learn more about the MSD Manuals and our commitment to Global Medical
Knowledge. [/en/professional/resourcespages/global-medical-knowledge]

<div class="para" > Glucosamine is claimed to relieve pain due to osteoarthritis, possibly with both analgesic and disease-modifying effects. Mechanism is unknown. Mechanism for glucosamine sulfate may be related to improved glycosaminoglycan synthesis as a result of the sulfate moiety. Dosage of glucosamine in all its forms is 500 mg orally 3 times a day.</div>

Claims

<div class="para" > Evidence supports use of glucosamine sulfate from Rotta Research Laboratorium for treatment of mild-to-moderate osteoarthritis of the knee when given for at least 6 months ( <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597" data-toggle="tooltip" title ="References" data-id="b3cad525-02dd-42db-8654-66ed89319212" data-itemid="7b7b34cc-5bd9-4133-a396-db21f214899e">2-3</a> <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597"> References Glucosamine is a precursor of multiple cartilage constituents. It is extracted from chitin (in shells of crabs, oysters, and shrimp) and is taken in tablet or capsule form, usually as glucosamine... read more </a> ). Other formulations still need to be rigorously evaluated. The role of glucosamine sulfate in the treatment of more severe knee osteoarthritis and osteoarthritis in other locations is less well-defined. </div>

Evidence

<div class="para" > Allergy (in patients who have shellfish allergy and take forms extracted from shellfish), dyspepsia, fatigue, insomnia, headache, photosensitivity, and nail changes may occur. Patients with chronic liver disease should also avoid glucosamine if possible, because of potential hepatotoxicity when taking glucosamine with or without chondroitin ( <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597" data-toggle="tooltip" title ="References" data-id="3f73ca26-7cf1-4d15-81ac-f594ddcf9a56" data-itemid="7b7b34cc-5bd9-4133-a396-db21f214899e">8</a> <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597"> References Glucosamine is a precursor of multiple cartilage constituents. It is extracted from chitin (in shells of crabs, oysters, and shrimp) and is taken in tablet or capsule form, usually as glucosamine... read more </a> ).</div>

Adverse Effects

<div class="para" > High-dose glucosamine may interact with warfarin and result in bruising or bleeding, according to case reports and information submitted to the World Health Organization. No other important drug interactions are known.</div>

Drug Interactions

<div class="para" > 1. <a rel="noopener nofollow" target="_blank" href="http://pubag.nal.usda.gov/pubag/article.xhtml?id=597740">Liu L, Liu Y, Shin HD, et al</a>: Microbial production of glucosamine and N-acetylglucosamine: advances and perspectives. Appl Microbiol Biotechnol 97(14):6149-6158, 2013. doi: 10.1007/s00253-013-4995-6</div>

References

<div class="para" > The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.</div>

More Information

v1126638

Additional Content

Also of Interest

Drug Name

The link you have selected will take you to a third-party website. We do not control or have responsibility for the content of any third-party site.

Leave this Site? 

Google+

Key Chapters Consumer

Key Topics it this Section

Language Fallback

Original title:

Generic Drug Names A - Z

LinkedIn

The following topic from a MSD Manual has been sent to you: 
%0D%0A
%0D%0A
{title} 
%0D%0A
%0D%0A
{link} 

Mail

Drug Information

Odnoklassniki

Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

<h4>Advanced Search:</h4>
<ul>
 <li>Use &ldquo; &ldquo; for exact phrases.
 <ul>
 <li>For example: &ldquo;pediatric abdominal pain&rdquo;</li>
 </ul>
 </li>
 <li>Use &ndash; to remove results with certain keywords.
 <ul>
 <li>For example: abdominal pain -pediatric</li>
 </ul>
 </li>
 <li>Use OR to account for alternate keywords.
 <ul>
 <li>For example: teenager OR adolescent</li>
 </ul>
 </li>
</ul>

Enter search terms to find related medical topics, multimedia and more.

Search results for:

Information that is clear and easy to understand on thousands of medical disorders and symptoms

Learn about SectionName symptoms, diagnosis and treatment in the MSD Manual. HCP and Vet versions too!

Learn about $TopicName symptoms, diagnosis and treatment in the MSD Manual. HCP and Vet versions too!