Classification of Rapidly Progressive Glomerulonephritis Based on Immunofluorescence Microscopy
Type | Percentage of RPGN Cases | Causes |
|---|---|---|
Anti-GBM antibody–mediated | ≤ 10% | Anti-GBM GN (without lung hemorrhage*) Goodpasture syndrome (with lung hemorrhage) |
Immune complex-mediated | ≤ 40% | Postinfectious causes:
Systemic rheumatic diseases:
Other glomerulopathies:
|
Pauci-immune | ≤ 50% | Granulomatosis with polyangiitis Renal-limited vasculitis (eg, idiopathic crescentic GN) |
Double-antibody positive | Rare | Same as for anti-GBM antibody-mediated and pauci-immune types |
* When the lung is also affected, anti-GBM glomerulonephritis is called Goodpasture syndrome. | ||
GBM = glomerular basement membrane; GN = glomerulonephritis; RPGN = rapidly progressive glomerulonephritis; IgA = immunoglobulin A. | ||