Дозування ванкоміцину для новонароджених
Serum Creatinine (mg/dL) | Dose* (IV) | Interval of Administration | |
|---|---|---|---|
≤ 28 Week Gestation | > 28 Week Gestation | ||
< 0.5 | < 0.7 | 15 mg/kg | Every 12 hours |
0.5–0.7 | 0.7–0.9 | 20 mg/kg | Every 24 hours |
0.8–1 | 1–1.2 | 15 mg/kg | Every 24 hours |
1.1–1.4 | 1.3–1.6 | 10 mg/kg | Every 24 hours |
> 1.4 | > 1.6 | 15 mg/kg | Every 48 hours |
* Dose is given by slow IV infusion, over at least 60 minutes. Begin with a 20 mg/kg loading dose. Ideally, adjust dosage to achieve 24 hours AUC:MIC of 400 mg • hours/L. If this calculation cannot be done, monitor serum trough level (target typically = 10–12 mcg/mL [6.9–8.3 micromol/L]). | |||
AUC = area under the plasma concentration–time curve; MIC = minimum inhibitory concentration. | |||
Adapted from Bradley JS, Nelson JD: Nelson's Pediatric Antimicrobial Therapy, ed. 24. Itasca, American Academy of Pediatrics, 2018. | |||