Ендокринні пухлини підшлункової залози

Tumor

Hormone

Tumor Location

Symptoms and Signs

ACTHoma

ACTH

Pancreas

Cushing syndrome

Gastrinoma

Gastrin

Duodenum (60%)

Pancreas (30%)

Other (10%)

Abdominal pain, peptic ulcer, diarrhea

Glucagonoma

Glucagon

Pancreas

Glucose intolerance, rash, weight loss, anemia

GRFoma

Growth hormone–releasing factor

Lungs (54%)

Pancreas (30%)

Jejunum (7%)

Other (13%)

Acromegaly

Insulinoma

Insulin

Pancreas

Fasting hypoglycemia

Somatostatinoma

Somatostatin

Pancreas (56%)

Duodenum/jejunum (44%)

Glucose intolerance, diarrhea, gallstones

Vipoma

Vasoactive intestinal peptidase

Pancreas (90%)

Other (10%)

Severe watery diarrhea, hypokalemia, flushing

ACTH = adrenocorticotropic hormone.

Data from Tong Gan, B. Mark Evers, Small Intestine. In Sabiston Textbook of Surgery, 21st edition. Editors: Courtney Townsend, R. Daniel Beauchamp, B. Mark Evers, Kenneth Mattox, New York, Elsevier, 2021, pp.1276-1282.