Пероральні антикоагулянти

Factor Xa inhibitors

Apixaban

Dosage may be lowered after 6–12 months of treatment.

Edoxaban

Initial treatment with heparin is needed for 5–10 days.

Edoxaban should not be used if creatinine clearance is < 15 mL/minute (< 0.25 mL/second).

Rivaroxaban

Rivaroxaban should not be used for DVT or PE if creatinine clearance is < 30 mL/minute (< 0.5 mL/second).

Dosage may be lowered to 10 mg once/day after 6–12 months of treatment.

Factor IIa (thrombin) inhibitor

Dabigatran

Initial treatment with heparin is needed for 5–10 days.

Dabigatran should not be used for DVT if creatinine clearance is < 30 mL/minute.