Непіоїдні анальгетики
Class | Drug | Usual Dosage Range* |
|---|---|---|
Indoles | Diclofenac | 50–100 mg, followed by 50 mg every 8 hours 75 mg every 12 hours IV or IM |
Etodolac | 200–400 mg every 6–8 hours | |
Indomethacin | 25–50 mg every 6–8 hours | |
Sulindac | 150–200 mg every 12 hours | |
Tolmetin | 200–400 mg every 6–8 hours | |
Naphthylalkanone | Nabumetone | 1000–2000 mg every 24 hours |
Oxicam | Piroxicam | 20–40 mg every 24 hours |
Para-aminophenol derivative | Acetaminophen | 650–1000 mg every 6–8 hours |
Propionic acids | Fenoprofen | 200–600 mg every 6 hours |
Flurbiprofen | 50–200 mg every 12 hours | |
Ibuprofen† | 400 mg every 4 hours to 800 mg every 8 hours (maximum: 3200 mg/day†) | |
Ketoprofen | 25–50 mg every 6–8 hours | |
Naproxen | 250–500 mg every 12 hours | |
Naproxen sodium | 275–550 mg every 12 hours | |
Oxaprozin | 600–1200 mg every 24 hours | |
Salicylates | Aspirin | 650–1000 mg every 4–6 hours |
Choline magnesium trisalicylate | 870 mg every 12 hours | |
Diflunisal | 250–500 mg every 8–12 hours | |
Salsalate | 750–2000 mg every 12 hours | |
Fenamates | Meclofenamate | 50–100 mg every 6–8 hours |
Mefenamic acid | 250 mg every 6 hours | |
Pyrazole | Phenylbutazone | 100 mg every 6–8 hours up to 7 days |
Pyrrolo-pyrrolo derivative | Ketorolac | 15–30 mg IV or IM every 6 hours or 20 mg orally, followed by 10 mg orally every 4–6 hours for maximum 5 days (assess creatinine every 4–6 doses, particularly in patients who are older or at risk of renal failure [eg, postoperative patients]) |
Selective COX-2 inhibitor | Celecoxib | 100–200 mg every 12 hours |
* Route is oral, except for ibuprofen, ketorolac, diclofenac, and acetaminophen, which can be given parenterally as well as orally. There is a topical form of diclofenac. | ||
† For ibuprofen, dosages ≤ 2400 mg reduce cardiovascular risk and are recommended for patients with cardiovascular risk factors. | ||
COX = cyclooxygenase. | ||