Вплив старіння на метаболізм і виведення деяких ліків
Class or Category | Decreased Hepatic Metabolism | Decreased Renal Elimination |
|---|---|---|
Analgesics and anti-inflammatory drugs | Diclofenac Ibuprofen Meperidine Morphine Naproxen | Meperidine Morphine Oxycodone |
Antidiabetic drugs | — | Alogliptin Canagliflozin Chlorpropamide Dapagliflozin Empagliflozin Ertugliflozin Exenatide Glimepiride Glyburide Lixisenatide Metformin Saxagliptin Sitagliptin |
Antimicrobial agents | — | Amikacin Ciprofloxacin Gentamicin Levofloxacin Nitrofurantoin Streptomycin Tobramycin Trimethoprim |
Cardiovascular drugs | Amlodipine Diltiazem Lidocaine† Nifedipine Propranolol Quinidine Verapamil Warfarin | N-Acetylprocainamide Apixaban Captopril Dabigatran Digoxin Dofetilide Edoxaban Enalapril Enoxaparin Heparin Lisinopril Procainamide Quinapril Rivaroxaban |
Diuretics | — | Amiloride Furosemide Hydrochlorothiazide Spironolactone Triamterene |
Psychoactive drugs | Alprazolam† Chlordiazepoxide Desipramine† Diazepam Imipramine Nortriptyline Trazodone Triazolam† | Brexpiprazole Lurasidone Paliperidone Risperidone |
Others‡ | Cimetidine Levodopa Theophylline | Allopurinol Amantadine Cimetidine Famotidine Gabapentin Lithium Metoclopramide Oseltamivir Ranitidine |
* When aging’s effect on hepatic metabolism of a drug is controversial, effects reported in the majority of studies are listed. | ||
† The effect occurs in men but not in women. | ||
‡ The drugs listed are examples only and not an exhaustive list. | ||