Депо антипсихотичні препарати
Drug* | Dosage | Peak Level† |
|---|---|---|
Aripiprazole, long-acting, injectable | 300–400 mg every month | 5–7 days |
Fluphenazine decanoate | 12.5–50 mg every 2–4 weeks | 1 day |
Fluphenazine enanthate | 12.5–50 mg every 1–2 weeks | 2 days |
Haloperidol decanoate | 25–150 mg every 28 days (3- to 5-week range is acceptable) | 7 days |
Olanzapine pamoate‡ | 210–300 mg every 2 weeks or 300–405 mg every 4 weeks | 7 days |
Paliperidone | 234 mg on day 1; 156 mg on day 8; then 117 mg once monthly (dose range 39–234 mg monthly) starting 5 weeks later | 13 days |
Risperidone microspheres§ | 12.5–50 mg every 2 weeks | 35 days |
* Drugs are given IM with Z-track technique. | ||
† Time until peak level after a single dose is listed. | ||
‡ Olanzapine pamoate may cause rare but significant sedation, so patients must be observed for 3 hours after the injection. | ||
§ Because of a 3-week lag time between first injection and achievement of adequate blood levels, patients should continue taking oral antipsychotics for 3 weeks after the first injection. Assessment of tolerability with oral risperidone is recommended before initiating IM therapy. | ||