Причини лімфоцитопенії
Mechanism | Examples |
|---|---|
Acquired | HIV infection and other viral infections (eg, COVID-19, Ebola disease, Epstein-Barr virus infection, hepatitis, influenza) Bacterial infections (eg, tuberculosis, typhoid fever, sepsis) Dietary deficiency in patients with alcohol use disorder, protein-energy undernutrition, or zinc deficiency Protein losing enteropathy Iatrogenic after use of cytotoxic chemotherapy, glucocorticoids, high-dose psoralen and ultraviolet A radiation therapy, lymphocyte antibody therapy, immunosuppressants, radiation therapy, or thoracic duct drainage Systemic disorders with autoimmune features (eg, aplastic anemia, Hodgkin lymphoma, myasthenia gravis, protein-losing enteropathy, rheumatoid arthritis, chronic kidney disease, sarcoidosis, systemic lupus erythematosus, thermal injury) |
Hereditary | Aplasia of lymphopoietic stem cells Cartilage-hair hypoplasia syndrome Idiopathic CD4+ T lymphocytopenia Immunodeficiency with thymoma Severe combined immunodeficiency associated with a defect in the interleukin-2 receptor gamma-chain, deficiency of ADA or PNP, or an unknown defect |
ADA = adenosine deaminase; PNP = purine nucleoside phosphorylase. | |