Лікування стафілококових інфекцій у дорослих антибіотиками
Infection | Antibiotics |
|---|---|
Community-acquired cutaneous infections (non-MRSA) | Dicloxacillin or cephalexin 250–500 mg orally every 6 hours for 7–10 days |
Penicillin-allergic patients | Erythromycin 250–500 mg orally every 6 hours Clarithromycin 500 mg orally every 12 hours Azithromycin 500 mg orally on the first day, then 250 mg orally every 24 hours on days 2–5 Clindamycin 300 mg orally every 6 hours |
Community-acquired cutaneous infections likely to be due to MRSA | Trimethoprim/sulfamethoxazole 160/800 mg orally every 8–12 hours Clindamycin 300–450 mg orally every 6–8 hours Linezolid 600 mg orally every 12 hours Tedizolid 200 mg orally every 24 hours Delafloxacin 450 mg orally every 12 hours Omadacycline 450 mg orally once a day for 2 days, followed by 300 mg once a day |
Sulfa-allergic patients | Clindamycin 600 mg orally every 8 hours Linezolid 600 mg orally every 12 hours Tedizolid 200 mg orally every 24 hours Doxycycline 100 mg orally every 12 hours Delafloxacin 450 mg orally every 12 hours Omadacycline 450 mg orally once a day for 2 days, followed by 300 mg once a day |
Serious infections unlikely to be due to MRSA | Nafcillin or oxacillin 1–2 g IV every 4–6 hours Cefazolin 1–2 g IV every 8 hours |
Penicillin-allergic patients | Clindamycin 600 mg IV every 8 hours Vancomycin 15 mg/kg every 12 hours |
Serious infection highly likely to be due to MRSA | Vancomycin 15 mg/kg IV every 12 hours Linezolid 600 mg IV every 12 hours, tedizolid 200 mg IV every 24 hours Daptomycin 4–10 mg/kg every 24 hours, depending on site of infection (not for pulmonary infections) Ceftobiprole 500 mg IV every 8 hours (not available in the United States) Ceftaroline 600 mg IV every 12 hours Delafloxacin 300 mg IV every 12 hours Omadacycline 200 mg IV once, followed by 100 mg IV every 24 hours |
Documented MRSA | By reported sensitivities |
Vancomycin-resistant staphylococci* | Linezolid 600 mg IV every 12 hours Quinupristin/dalfopristin 7.5 mg/kg every 8 hours Daptomycin 4–8 mg/kg every 24 hours Oritavancin 1200 mg IV once Ceftobiprole 500 mg IV every 8 hours (not available in the United States) Ceftaroline 600 mg IV every 12 hours |
* No clinical data are available, but listed antibiotics appear to be active in vitro. | |
MRSA = methicillin-resistant Staphylococcus aureus. | |