[{"Title":"Етіологія","UniqueID":"v963040_uk","Index":1.0,"Summary":"

Etiology of pyoderma gangrenosum is unknown, but it can be associated with various systemic illnesses, including inflammatory bowel disease Загальні відомості про запальні захворювання кишечника , rheumatoid arthritis Ревматоїдний артрит (РА) $\"Ревматоїдний$ , cancers, and hematologic disorders (eg, monoclonal gammopathy of undetermined significance Моноклональна гаммапатія невизначеного значення (MGUS) , myelodysplastic syndrome Мієлодиспластичний синдром (МДС) , polycythemia vera справжня поліцитемія ). It is thought to be mediated by an abnormal immune response.

","HeadType":"F_Head","SchemeItemProp":"itemprop=\"cause\" itemscope itemtype=\"http://schema.org/MedicalCause\"","Children":[{"Title":"Довідковий матеріал щодо етіології","UniqueID":"v91002878_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"cause\" itemscope itemtype=\"http://schema.org/MedicalCause\"","Children":[]}]},{"Title":"Патофізіологія","UniqueID":"v963043_uk","Index":2.0,"Summary":"

Pathophysiology of pyoderma gangrenosum is poorly understood but may involve problems with neutrophil chemotaxis. Interleukin-8 is overexpressed in lesions.

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідковий матеріал щодо патофізіології","UniqueID":"v91002886_uk","Index":1.0,"Summary":"

Pathophysiology of pyoderma gangrenosum is poorly understood but may involve problems with neutrophil chemotaxis. Interleukin-8 is overexpressed in lesions.

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Симптоми та ознаки","UniqueID":"v963046_uk","Index":3.0,"Summary":"

Most often, pyoderma gangrenosum begins as an inflamed, erythematous papule, pustule, or nodule. The lesion, which may resemble a furuncle or an arthropod bite at this stage, ulcerates and expands rapidly, developing a swollen necrotic base and a raised dusky to violaceous border. An undermined border (ie, loss of underlying support tissue at the border) is common, if not pathognomonic. The ulcers can coalesce to form larger ulcers, often with cribriform or sieve-like scarring.

","HeadType":"F_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[{"Title":"Виразковий (класичний) підтип","UniqueID":"v49399262_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]},{"Title":"Бульозний (атиповий) підтип","UniqueID":"v49399266_uk","Index":2.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]},{"Title":"Пустульозний підтип","UniqueID":"v49399270_uk","Index":3.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]},{"Title":"Вегетативний (поверхнева гранулематозна піодермія) підтип","UniqueID":"v49399273_uk","Index":4.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]},{"Title":"Інші підтипи","UniqueID":"v49399277_uk","Index":5.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]}]},{"Title":"Діагностика","UniqueID":"v963050_uk","Index":4.0,"Summary":"

Clinical evaluation

","HeadType":"F_Head","SchemeItemProp":"","Children":[]},{"Title":"Лікування","UniqueID":"v963053_uk","Index":5.0,"Summary":"

Wound care

","HeadType":"F_Head","SchemeItemProp":"itemprop=\"possibleTreatment\" itemscope itemtype=\"http://schema.org/MedicalTherapy\"","Children":[{"Title":"Довідковий матеріал щодо лікування","UniqueID":"v49399281_uk","Index":1.0,"Summary":"

Wound care

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"possibleTreatment\" itemscope itemtype=\"http://schema.org/MedicalTherapy\"","Children":[]}]},{"Title":"Ключові моменти","UniqueID":"v9126891_uk","Index":6.0,"Summary":"

Pyoderma gangrenosum is often associated with a systemic disorder and is probably immune-mediated.

","HeadType":"F_Head","SchemeItemProp":"","Children":[]}]