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Manganese Deficiency

ByLarry E. Johnson, MD, PhD, University of Arkansas for Medical Sciences
Reviewed/Revised May 2025
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Manganese (Mn), necessary for healthy bone structure, is a component of several enzyme systems, including manganese-specific glycosyltransferases and phosphoenolpyruvate carboxykinase. Median intake is between 1.6 and 2.3 mg/day; absorption is 5 to 10%.

Manganese deficiency has not been conclusively documented. In an experimental study, severe manganese restriction led to dermatitis and hypocholesterolemia (has not been conclusively documented. In an experimental study, severe manganese restriction led to dermatitis and hypocholesterolemia (1).

Reference

  1. 1. Friedman BJ, Freeland-Graves JH, Bales CW, et al. Manganese balance and clinical observations in young men fed a manganese-deficient diet. . Manganese balance and clinical observations in young men fed a manganese-deficient diet.J Nutr. 1987 Jan;117(1):133-43. doi: 10.1093/jn/117.1.133

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