Some Factors Commonly Contributing To Prolonged Or Chronic Fatigue

Category

Examples

Chronic disorders

Chronic kidney disease, rheumatologic disorders (eg, giant cell arteritis, rheumatoid arthritis, systemic lupus erythematosus)

Drugs

Endocrine disorders

Adrenal insufficiency*, diabetes, hyperthyroidism* (usually apathetic), hypothyroidism, pituitary insufficiency

Infections

Cytomegalovirus infection, endocarditis, fungal pneumonias, hepatitis, HIV/AIDS, mononucleosis, parasitic infections*, tuberculosis, SARS, COVID-19

Psychologic disorders

Anxiety, depression, domestic violence, drug addiction, panic disorder, somatization disorder

Disorders of unknown cause

Myalgic encephalomyelitis/chronic fatigue syndrome, fibromyalgia, idiopathic fatigue

Other causes

Anemias, cancers, deconditioning, pregnancy*, undernutrition, hypercalcemia*, multiple sclerosis

* Usually does not cause chronic fatigue.

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