Professional edition active

Oral Calcium Channel Blockers for Hypertension

Medication

Selected Adverse Effects

Comments

Dihydropyridines

AmlodipineAmlodipine

Dizziness, flushing, headache, weakness, nausea, heartburn, peripheral edema, tachycardia

Possible gingival hyperplasia with chronic use

Contraindicated in heart failure, possibly except for amlodipineContraindicated in heart failure, possibly except for amlodipine

Use of short-acting nifedipine possibly associated with higher rate of myocardial infarctionUse of short-acting nifedipine possibly associated with higher rate of myocardial infarction

FelodipineFelodipine

IsradipineIsradipine

NicardipineNicardipine

Nicardipine, sustained-releaseNicardipine, sustained-release

Nifedipine, extended-releaseNifedipine, extended-release

NisoldipineNisoldipine

Nondihydropyridines

Diltiazem, sustained-releaseDiltiazem, sustained-release

Headache, dizziness, asthenia, flushing, peripheral edema, bradycardia; possibly liver dysfunction

Possible gingival hyperplasia with chronic use

Verapamil: ConstipationVerapamil: Constipation

Contraindicated in heart failure with reduced ejection fraction due to negative inotropic effects, in sinus node dysfunction, or in greater than first-degree atrioventricular block

Diltiazem, extended-releaseDiltiazem, extended-release

VerapamilVerapamil

Verapamil, sustained-releaseVerapamil, sustained-release