Common Substances That Interact With Cytochrome P-450 Enzymes
Enzyme | Substrates | Inhibitors | Inducers |
|---|---|---|---|
CYP1A2 | Caffeine Tacrine Tricyclic antidepressants (R) | Ticlopidine | Charcoal-broiled beef Cigarette smoke |
CYP2C9 | Tricyclic antidepressants (S) | Sulfamethoxazole | Other barbiturates |
CYP2C19 | (S)-Mephenytoin (R) | Ticlopidine | |
CYP2D6 | Beta blockers Phenothiazines Selective serotonin reuptake inhibitors Tricyclic antidepressants | ||
CYP2E1 | Alcohol | Alcohol Tobacco use | |
CYP3A4 | Azole antifungals Benzodiazepines Calcium channel blockers Caffeine Estrogen Lopinavir Opioid analgesics Statins Tricyclic antidepressants (R) | Amprenavir Azole antifungals Grapefruit juice Propoxyphene |
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