Classification of Neutropenias
Classification | Etiology |
|---|---|
Neutropenia due to intrinsic defects in myeloid cells or their precursors | Chronic idiopathic neutropenia Severe congenital neutropenias (typically Kostmann syndrome) Neutropenia associated with dysgammaglobulinemia Paroxysmal nocturnal hemoglobinuria Syndrome-associated neutropenias (eg, cartilage-hair hypoplasia syndrome, dyskeratosis congenita, glycogen storage disease type IB, WHIM* syndrome, Shwachman-Diamond syndrome) |
Secondary neutropenias | Drug-induced neutropenia Cytotoxic chemotherapy or radiation therapy Infection Autoimmune neutropenia, including chronic secondary neutropenia in AIDS Bone marrow replacement (eg, due to cancer, myelofibrosis, granuloma, or Gaucher cells) Folate deficiency, vitamin B12 deficiency, or severe undernutrition Hypersplenism T cell large granular lymphocyte disease |
* WHIM = warts, hypogammaglobulinemia, infections, myelokathexis. | |