Oxygen Desaturation

Very sudden onset dyspnea and hypoxia suggest pulmonary embolus (PE) or pneumothorax (mainly in a patient receiving positive pressure ventilation). Fever, chills, and productive cough (or increased secretions) suggest pneumonia. A history of cardiopulmonary disease (eg, asthma, chronic obstructive pulmonary disease, heart failure) may indicate an exacerbation of the disease. Symptoms and signs of myocardial infarction may indicate acute valvular insufficiency, pulmonary edema, or cardiogenic shock. Unilateral extremity pain suggests deep venous thrombosis (DVT) and hence possible PE. Preceding major trauma or sepsis requiring significant resuscitation suggests acute respiratory distress syndrome. Renal failure indicates higher risk of fluid overload. Preceding chest trauma suggests pulmonary contusion.

Patency of the airway and strength and adequacy of respirations should be assessed immediately. For patients on mechanical ventilation, it is important to determine that the endotracheal tube is not obstructed or dislodged. Findings are suggestive as follows:

• Unilateral decreased breath sounds with clear lung fields suggest pneumothorax or right mainstem bronchus intubation; with crackles and fever, pneumonia is more likely.

• Distended neck veins with bilateral lung crackles suggest volume overload with pulmonary edema, cardiogenic shock, pericardial tamponade (often without crackles), or acute valvular insufficiency.

• Distended neck veins with clear lungs or unilateral decrease in breath sounds and tracheal deviation suggest tension pneumothorax.

• Bilateral lower-extremity edema suggests heart failure, but unilateral edema suggests DVT and hence possible PE.

• Wheezing represents bronchospasm (typically asthma or allergic reaction, but it occurs rarely with PE or heart failure).

• Decreased mental status suggests hypoventilation.

Hypoxia is generally recognized initially by pulse oximetry. Patients should have the following:

• A chest x-ray (eg, to assess for pneumonia, pleural effusion, pneumothorax, heart failure, or atelectasis)

• ECG (to assess for arrhythmia or ischemia)

• Arterial blood gases (ABGs), to confirm hypoxia and evaluate adequacy of ventilation

Bedside echocardiography done by an intensivist may be used to assess for hemodynamically significant pericardial effusion or reduced global left ventricular or right ventricular function until formal echocardiography can be done. Bedside ultrasonography can also be done to identify pneumothorax. Elevated serum levels of brain (B-type) natriuretic peptide (BNP) may help differentiate heart failure from other causes of hypoxia. If diagnosis remains unclear after these tests, testing for PE should be considered. Bronchoscopy may be done in intubated patients or in patients with a tracheostomy to rule out (and remove) a tracheobronchial mucous plug.

The amount of oxygen given is guided by arterial blood gases (ABG) or pulse oximetry to maintain PaO2 between 60 and 80 mm Hg (ie, 92 to 100% saturation) without causing oxygen toxicity. This level provides satisfactory tissue oxygen delivery; because the oxyhemoglobin dissociation curve is sigmoidal, increasing PaO2 to > 80 mm Hg increases oxygen delivery very little and is not necessary. The lowest fractional inspired oxygen (FiO2) that provides an acceptable PaO2 should be provided. Oxygen toxicity is

• Concentration-dependent

• Time-dependent

Sustained elevations in FiO2 > 60% result in inflammatory changes, alveolar infiltration, and, eventually, pulmonary fibrosis. An FiO2 > 60% should be avoided unless necessary for survival. An FiO2 < 60% is well tolerated for long periods.

An FiO2 < 40% can be given via nasal cannula or simple face mask. A nasal cannula uses an oxygen flow of 1 to 6 L/minute. Because 6 L/minute is sufficient to fill the nasopharynx, higher flow rates are of no benefit. Simple face masks and nasal cannulas do not deliver a precise FiO2 because of inconsistent admixture of oxygen with room air from leakage and mouth breathing. However, Venturi-type masks can deliver very accurate oxygen concentrations.

Clinical Calculators

Oxygen Delivery Units Conversions

An FiO2 > 40% requires use of an oxygen mask with a reservoir that is inflated by oxygen from the supply. In the typical nonrebreather mask, the patient inhales 100% oxygen from the reservoir, but during exhalation, a rubber flap valve diverts exhaled breath to the environment, preventing admixture of carbon dioxide and water vapor with the inspired oxygen. Nonetheless, because of leakage, such masks deliver an FiO2 of at most 80 to 90%.

High-flow nasal cannula (HFNC) oxygen therapy, in contrast to traditional nasal oxygen, delivers oxygen at rates from 20 to 60 L/minute; the oxygen is humidified. Humidification helps prevent airway desiccation and inflammation, maintain mucociliary function, and improve mucus clearance. HFNC therapy tends to wash out upper airway dead space and decrease the work of breathing more than non-rebreather masks. This therapy may help patients with hypoxemic respiratory failure not due to heart failure and who are not hypercapneic.

Refractory hypoxia may require neuromuscular blockade, recruitment maneuvers, prone ventilation, or venovenous extracorporeal membrane oxygenation (ECMO).