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Daptomycin

ByBrian J. Werth, PharmD, University of Washington School of Pharmacy
Reviewed/Revised May 2024
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The antibiotic daptomycin is used to treat many serious bacterial infections, such as those caused by The antibiotic daptomycin is used to treat many serious bacterial infections, such as those caused bygram-positive bacteria, including those that are resistant to many other antibiotics.

Daptomycin works by interfering with the bacteria's cell membrane, which results in rapid death of the bacteria.

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(See also Overview of Antibiotics.)

Use of Daptomycin During Pregnancy and Breastfeeding

Daptomycin should be used during pregnancy only when the benefits of treatment outweigh the risks. (See also Daptomycin should be used during pregnancy only when the benefits of treatment outweigh the risks. (See alsoSafety of Medications During Pregnancy.)

Whether daptomycin is safe to use during breastfeeding is unknown. (See also Medication and Substance Use During Breastfeeding.)

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