Whipple disease is the result of a rare bacterial infection that damages the lining of the small intestine, resulting in malabsorption, and may involve other organs of the body.
This disease is caused by a bacterial infection.
Typical symptoms include diarrhea, inflamed and painful joints, weight loss, and abdominal pain.
The diagnosis is based on the results of biopsies of the small intestine.
If left untreated, the disease is progressive and fatal.
Antibiotics can eliminate the infection, but the disease can recur.
Whipple disease affects mainly White men aged 30 to 60.
Causes of Whipple Disease
Whipple disease is caused by an infection with the organism Tropheryma whipplei. The infection almost always affects the small intestine but can affect other organs, such as the heart, lungs, brain, joints, and eyes.
Symptoms of Whipple Disease
The four main symptoms of Whipple disease are
Inflamed and painful joints
Diarrhea
Abdominal pain
Weight loss
Other common symptoms are fever, loss of appetite, fatigue and weakness caused by anemia, cough, and pain when breathing caused by inflammation of the membrane layers covering the lungs (pleura). Fluid may collect in the space between the pleural layers (a condition called pleural effusion). The lymph nodes may become enlarged.
In some people, the skin becomes darker.
People with Whipple disease may develop heart murmurs.
Confusion, memory loss, or uncontrolled eye movements indicate that the infection has spread to the brain.
Diagnosis of Whipple Disease
Biopsy
A doctor can make the diagnosis of Whipple disease by identifying bacteria in the small intestine.
To identify the bacteria, doctors remove tissue (biopsy) from the small intestine using an endoscope (a flexible viewing tube equipped with a light source and a camera through which a small clipper can be inserted) or remove tissue from an enlarged lymph node. The tissue is then examined under a microscope.
Treatment of Whipple Disease
Antibiotics
If left untreated, Whipple disease becomes progressively worse and is fatal.
Despite an initial response to antibiotics, however, the disease can come back.
