Dosing of Oral First-Line Anti-TB Drugs*
Drug | Adults or Children | Daily† | Once/Week | 2 Times/Week | 3 Times/Week |
|---|---|---|---|---|---|
Adults (maximum) | 5 mg/kg (300 mg) | 15 mg/kg (900 mg) | 15 mg/kg (900 mg) | 15 mg/kg (900 mg) | |
Children (maximum) | 10–20 mg/kg (300 mg) | N/A | 20–40 mg/kg (900 mg) | N/A | |
Adults (maximum) | 10 mg/kg (600 mg) | N/A | 10 mg/kg (600 mg) | 10 mg/kg (600 mg) | |
Children (maximum) | 10–20 mg/kg (600 mg) | N/A | 10–20 mg/kg (600 mg) | N/A | |
Adults (maximum) | 5 mg/kg (300 mg) | N/A | 5 mg/kg (300 mg) | 5 mg/kg (300 mg) | |
Children | 10–20 mg/kg (300 mg) | N/A | 10–20 mg/kg (300 mg) | 10–20 mg/kg (600 mg) | |
Adults | N/A | 10 mg/kg (600 mg) | N/A | N/A | |
Children | N/A | N/A | N/A | N/A | |
Adults (whole tablets): | |||||
40–55 kg | 1 g | N/A | 2 g | 1.5 g | |
56–75 kg | 1.5 g | N/A | 3 g | 2.5 g | |
≥ 76 kg§ | 2 g | N/A | 4 g | 3 g | |
Children (maximum) | 15–30 mg/kg (2 g) | N/A | 50 mg/kg (2 g) | N/A | |
Adults (whole tablets): | |||||
40–55 kg | 800 mg | N/A | 2000 mg | 1200 mg | |
56–75 kg | 1200 mg | N/A | 2800 mg | 2000 mg | |
≥ 76 kg§ | 1600 mg | N/A | 4000 mg | 2400 mg | |
Children (maximum) | 15–20 mg/kg (1 g) | N/A | 50 mg/kg (2.5 g) | N/A | |
≥ 12 years of age | 400 mg | N/A | N/A | N/A | |
* Specific regimens are discussed in text. | |||||
† Daily is considered either 5 or 7 days/week. All dosing < 7 days/week must be given as directly observed therapy. | |||||
‡ Continuation phase only. | |||||
§ Maximum dose. | |||||
N/A = not applicable. | |||||