Sinusoidal Obstruction Syndrome

(Veno-Occlusive Disease)

ByWhitney Jackson, MD, University of Colorado School of Medicine
Reviewed/Revised May 2024
View Patient Education

Hepatic sinusoidal obstruction syndrome, formerly known as hepatic veno‐occlusive disease, is caused by endothelial injury, leading to nonthrombotic occlusion of the terminal hepatic venules and hepatic sinusoids, rather than of the hepatic veins or inferior vena cava (as in Budd-Chiari syndrome).

(See also Overview of Vascular Disorders of the Liver.)

Venous congestion causes portal hypertension and ischemic necrosis (which leads to cirrhosis).

Etiology of Sinusoidal Obstruction Syndrome

Common causes include

  • Irradiation

  • Graft-vs-host disease resulting from bone marrow or hematopoietic cell transplantation

  • Pyrrolizidine alkaloids in crotalaria and senecio plants (eg, medicinal bush teas) and other herbs (eg, comfrey)

Pearls & Pitfalls

  • Ask patients who have cryptogenic liver abnormalities about use of herbal and natural products (including bush and herb teas) and anabolic steroids (which can cause peliosis hepatis).

Symptoms and Signs of Sinusoidal Obstruction Syndrome

Initial manifestations include sudden jaundice, ascites, and tender, smooth hepatomegaly. Onset is within the first 3 weeks of transplantation in bone marrow or hematopoietic cell recipients, who either recover spontaneously within a few weeks (or sometimes, with mild cases, after an increase in immunosuppressant therapy) or die of fulminant liver failure. Other patients have recurrent ascites, portal hypertension, splenomegaly, and, eventually, cirrhosis.

Diagnosis of Sinusoidal Obstruction Syndrome

  • Clinical evaluation and liver tests

  • Ultrasonography

  • Sometimes invasive tests (eg, liver biopsy, measurement of portal-hepatic venous pressure gradient)

The diagnosis is suspected in patients with unexplained clinical or laboratory evidence of liver disease, particularly in those with known risk factors, such as bone marrow or hematopoietic cell transplantation.

Laboratory results are nonspecific: elevated aminotransferase and conjugated bilirubin levels. Prothrombin time/international normalized ratio (PT/INR) becomes abnormal when disease is severe. Ultrasonography shows retrograde flow in the portal vein.

If the diagnosis is unclear, liver biopsy and measurement of the portal-hepatic venous pressure gradient is definitive (a pressure gradient > 10 mm Hg is consistent with sinusoidal obstruction syndrome). Measuring the pressure across the liver entails inserting a catheter percutaneously into a hepatic vein and then wedging it into the liver. This wedged pressure reflects portal vein pressure. (An exception is portal vein thrombosis; in this case, the pressure is normal despite portal hypertension.)

Treatment of Sinusoidal Obstruction Syndrome

  • Supportive care

  • Treatment of cause

  • For progressive disease, transjugular intrahepatic portosystemic shunting or transplantation

graft-vs-host disease in bone marrow or hematopoietic stem cell transplant recipients (1, 2).

3).

Most patients have mild to moderate disease and do quite well. Transjugular intrahepatic portosystemic shunting (TIPS) can be tried for relief of portal hypertension but has not yet been shown to prolong survival, particularly when sinusoidal obstruction syndrome is severe. In 25%, sinusoidal obstruction syndrome is severe, accompanied by fulminant liver failure. Liver transplantation is a last resort in highly selected patients.

Treatment references

  1. 1. Northup PG, Garcia-Pagan JC, Garcia-Tsao G, et al: Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 73(1):366-413, 2021. doi: 10.1002/hep.31646

  2. 2. Tay J, Tinmouth A, Fergusson D, et alBiol Blood Marrow Transplant 13(2):206-17, 2007. doi: 10.1016/j.bbmt.2006.09.012

  3. 3. Richardson PG, Riches ML, Kernan NA, et alBlood 27(13):1656-1665, 2016.  doi: 10.1182/blood-2015-10-676924

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