Поширені речовини, які взаємодіють з ферментами цитохрому P-450
Enzyme | Substrates | Inhibitors | Inducers |
|---|---|---|---|
CYP1A2 | Acetaminophen Caffeine Clarithromycin Estradiol Haloperidol Lidocaine Methadone Olanzapine Propranolol Ritonavir Tacrine Theophylline Tricyclic antidepressants Verapamil (R)-Warfarin | Amiodarone Cimetidine Ciprofloxacin Erythromycin Fluvoxamine Ticlopidine | Charcoal-broiled beef Cigarette smoke Omeprazole Phenobarbital Phenytoin Rifampin |
CYP2C9 | Celecoxib Diclofenac Fluoxetine Glipizide Glyburide Indomethacin Nifedipine Phenytoin Piroxicam Progesterone Testosterone Tricyclic antidepressants Valproate Voriconazole (S)-Warfarin | Amiodarone Cimetidine Fluconazole Lovastatin Ritonavir Sertraline Sulfamethoxazole Topiramate Trimethoprim Voriconazole Zafirlukast | Dexamethasone Phenobarbital Other barbiturates Phenytoin Rifampin |
CYP2C19 | Diazepam (S)-Mephenytoin Omeprazole Pentamidine Propranolol Voriconazole (R)-Warfarin | Cimetidine Fluoxetine Fluvoxamine Ketoconazole Lansoprazole Omeprazole Paroxetine Ticlopidine | Carbamazepine Phenobarbital Prednisone Rifampin |
CYP2D6 | Beta blockers Codeine Dextromethorphan Flecainide Haloperidol Lidocaine Mexiletine Morphine Omeprazole Phenothiazines Quinidine Risperidone Selective serotonin reuptake inhibitors Tamoxifen Testosterone Tramadol Trazodone Tricyclic antidepressants Venlafaxine | Amiodarone Bupropion Celecoxib Cimetidine Fluoxetine Fluvoxamine Metoclopramide Methadone Paroxetine Quinidine Ritonavir Sertraline | Carbamazepine Dexamethasone Phenobarbital Phenytoin Rifampin |
CYP2E1 | Acetaminophen Alcohol | Disulfiram | Alcohol Isoniazid Tobacco use |
CYP3A4 | Amiodarone Aprepitant Azole antifungals Benzodiazepines Calcium channel blockers Caffeine Carbamazepine Clarithromycin Cyclosporine Delavirdine Enalapril Estradiol Estrogen Erythromycin Fentanyl Finasteride Indinavir Lidocaine Lopinavir Loratidine Methadone Nelfinavir Omeprazole Opioid analgesics Prednisone Progesterone Ritonavir Saquinavir Sildenafil Sirolimus Statins Tacrolimus Tamoxifen Tricyclic antidepressants (R)-Warfarin | Amiodarone Amprenavir Atazanavir Azole antifungals Cimetidine Ciprofloxacin Clarithromycin Delavirdine Diltiazem Erythromycin Fluoxetine Fluvoxamine Grapefruit juice Indinavir Metronidazole Nefazodone Nelfinavir Nifedipine Omeprazole Paroxetine Posaconazole Propoxyphene Ritonavir Saquinavir Sertraline Verapamil Voriconazole | Carbamazepine Dexamethasone Isoniazid Phenobarbital Phenytoin Prednisone Rifampin |