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Professional

Special Subjects

Dietary Supplements

Ginkgo

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<div class="para" > Ginkgo leaf products are used for minor symptomatic relief of claudication, although exercise and cilostazol may be more effective. Gingko increases the distance that affected people can walk without pain.</div>

Claims

<div class="para" > Ginkgo is thought to be a vasoactive agent. Although patients with intermittent claudication may be able to walk longer than placebo-treated patients, this benefit is quite minor according to a 2013 Cochrane review. This review looked at 14 trials with a total of 739 participants, of which 11 trials (477 participants) compared Ginkgo biloba to placebo ( <a href="/professional/special-subjects/dietary-supplements/ginkgo#v75591472" data-toggle="tooltip" title ="References" data-id="d17d4cbd-d0a0-44b5-8d2a-c99ebda9eb82" data-itemid="8d40e516-6b9a-4286-a011-68f2320d9acc">1</a> <a href="/professional/special-subjects/dietary-supplements/ginkgo#v75591472"> References Ginkgo (Ginkgo biloba) is prepared from leaves of the ginkgo tree (commonly planted in the US for ornamental purposes and botanically unique as it is the only surviving member of its... read more </a> ). </div>

Evidence

<div class="para" > Nausea, dyspepsia, headache, dizziness, and heart palpitations may occur. It should not be used by pregnant women because it may lead to early labor or excessive bleeding during childbirth. Gingko also should be stopped at least 2 weeks before surgery because of the potential for excessive bleeding.</div>

Adverse Effects

<div class="para" > Ginkgo may interact with aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), and warfarin; it also may reduce the efficacy of antiseizure medications. Ginkgo may precipitate serotonin syndrome in patients on other antidepressant medications ( <a href="/professional/special-subjects/dietary-supplements/ginkgo#v75591472" data-toggle="tooltip" title ="References" data-id="39e443a9-c551-4718-8fb2-94dee706654c" data-itemid="8d40e516-6b9a-4286-a011-68f2320d9acc">10</a> <a href="/professional/special-subjects/dietary-supplements/ginkgo#v75591472"> References Ginkgo (Ginkgo biloba) is prepared from leaves of the ginkgo tree (commonly planted in the US for ornamental purposes and botanically unique as it is the only surviving member of its... read more </a> ). (See also table <span class="multimedia__link mlinkBlock" data-bind="component: { name: 'm-link-text', params: $data }" data-popup-model='{"ItemId":"7bb0c74f-f879-45bb-8e22-81962410f458","Title":"Some%20Possible%20Dietary%20Supplement%E2%80%93Drug%20Interactions%2A","ShareUrlTitle":"some-possible-dietary-supplementdrug-interactions","Description":"","ImageUrl":null,"ThumbnailUrl":"/Base/table/icon_table_red.png?h=600\u0026w=600","MediaType":"table","MediaNameTranslated":"Table","UniqueId":"v1126013","Placement":null,"IsInCarousel":false,"Edition":0,"ImageWidth":null,"ImageHeight":null,"IframeSrc":null,"Target":null,"Alt":null}' data-popup-options='{"ListName":"TopicMultimedia","LinkText":"%3Cspan%20%3ESome%20Possible%20Dietary%20Supplement%E2%80%93Drug%20Interactions%3C%2Fspan%3E","CssClass":null,"LoadLocations":true,"ShowTooltip":true,"SingleItem":true,"ExcludeFromBrand":"","ShowCredits":true,"ShowDescription":true,"PopupTitle":"Table","ShowTitle":true,"ShowIcon":false,"ShowModalIndicator":false,"ShowTitleInHeader":false,"HideCarousel":false,"Target":"modal","Url":null,"HideMainArrows":false}' >.) </div>

Drug Interactions

<div class="para" > 1. <a rel="noopener nofollow" target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/23744597">Nicolaï SP, Kruidenier LM, Bendermacher BL, et al</a>: Gingko biloba for intermittent claudication. Cochrane Database Syst Rev 6: CD006888, 2013. doi: 10.1002/14651858.CD006888.pub3</div>

References

<div class="para" > The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.</div>

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