Substance-related disorders involve substances that directly activate the brain's reward system. The activation of the reward system typically causes feelings of pleasure; the specific characteristics of the pleasurable feelings evoked vary widely depending on the drug. These drugs are divided into 10 different classes that have different, although not completely distinct, pharmacologic mechanisms. The classes of drugs include
Hallucinogens (eg, LSD, phencyclidine
Inhalants (volatile hydrocarbons [eg, paint thinner, certain glues])
Stimulants (eg, amphetamines, )
Other (eg, anabolic steroids)
Use and cessation of substances may cause psychologic, behavioral, and physiologic changes, ie, intoxication and withdrawal. Substance misuse can also result in psychiatric disorders (eg, depression, psychosis, anxiety, or neurocognitive disorders).
Substance use disorders involve a pathologic pattern of behaviors in which patients continue to use a substance despite experiencing significant problems related to its use. There may also be physiologic manifestations, including changes in brain circuitry. The common terms "addiction," "abuse," and "dependence" are too loosely and variably defined to be very useful in systematic diagnosis; "substance use disorder" is more comprehensive and has fewer negative connotations.
Drugs in the 10 classes vary in how likely they are to cause a substance use disorder. The likelihood is termed addiction liability and depends upon a combination of factors including
Route of administration
Rate at which the drug crosses the blood-brain barrier and stimulates the reward pathway
Time to onset of effect
Ability to induce tolerance and/or withdrawal symptoms
Scheduled drugs
In the US, the Comprehensive Drug Abuse Prevention and Control Act of 1970 and subsequent modifications require the pharmaceutical industry to maintain physical security of and strict record keeping for certain classes of drugs (controlled substances—see table Some Examples of Controlled Substances). Controlled substances are divided into 5 schedules (or classes) on the basis of their potential for abuse, accepted medical use, and accepted safety under medical supervision. The schedule classification determines how a substance must be controlled.
Schedule I: These substances have a high addiction liability, no accredited medical use, and a lack of accepted safety. They can be used only under government-approved research conditions.
Schedule II to IV: These drugs have progressively less addiction liability (going from schedule II to IV). They have an accredited medical use. Prescriptions for these drugs must bear the physician’s federal Drug Enforcement Administration (DEA) license number.
Schedule V: These substances have the least addiction liability. Some Schedule V drugs do not require a prescription.
State schedules may vary from federal schedules.
Some Examples of Controlled Substances
Schedule | Examples |
|---|---|
I* | Cathinone (khat) and methcathinone, GHB, heroin (and some other opioids), LSD, MDMA, psilocybin, cannabis, and synthetic cannabinoids |
II | |
III | |
IV | |
V | |
* Cannot be prescribed. | |
GHB = gamma hydroxybutyrate; LSD = lysergic acid diethylamide; MDMA = methylenedioxymethamphetamine. | |
