Sporotrichosis

ByPaschalis Vergidis, MD, MSc, Mayo Clinic College of Medicine & Science
Reviewed/Revised Sept 2023
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Sporotrichosis is a cutaneous infection caused by the saprophytic mold Sporothrix schenckii. Pulmonary and hematogenous involvement is uncommon. Symptoms are cutaneous nodules that spread via lymphatics and break down into abscesses and ulcers. Diagnosis is by culture. Treatment is with itraconazole or amphotericin B.

(See also Overview of Fungal Infections.)

Sporothrix schenckii resides on rose or barberry bushes, in sphagnum moss, and in other mulches. Horticulturists, gardeners, farm laborers, and timber workers are most often infected, typically after minor trauma involving contaminated material. In contrast to the other dimorphic fungi, S. schenckii is not usually inhaled but enters the body through small cuts and abrasions in the skin.

Sporothrix schenckii is a dimorphic fungus, growing as a yeast in tissue and in culture at 37° C (98.6° F) but as a filamentous fungus at 30° C (86° F).

Symptoms and Signs of Sporotrichosis

Lymphocutaneous infections are most common. They characteristically involve one hand and arm, although they can occur anywhere on the body; primary lesions may occur on exposed surfaces of the feet or face.

A primary lesion may appear as a small, nontender papule or, occasionally, as a slowly expanding subcutaneous nodule that eventually becomes necrotic and sometimes ulcerates. Typically, a few days or weeks later, a chain of lymph nodes that drain the affected area begins to enlarge slowly but progressively, forming movable subcutaneous nodules. Without treatment, overlying skin reddens and may later necrose, sometimes causing an abscess, ulceration, and bacterial superinfection. Systemic symptoms and signs of infection are notably absent.

Manifestations of Sporotrichosis
Sporotrichosis (Papule)
Sporotrichosis (Papule)

Sporotrichosis starts as a small papule or subcutaneous nodule that may ulcerate or necrose.

Image courtesy of www.doctorfungus.org © 2005.

Sporotrichosis (Nodules)
Sporotrichosis (Nodules)

Sporotrichosis starts as a small papule or subcutaneous nodule that may ulcerate or necrose.

Image courtesy of www.doctorfungus.org © 2005.

Sporotrichosis (Abscess)
Sporotrichosis (Abscess)

Sporotrichosis starts as a small papule or subcutaneous nodule that may ulcerate or necrose. The infection spreads lymphatically. If untreated, diffuse erythema, ulcers, and abscesses may develop as is seen in this example of severe bacterial superinfection.

... read more

Image courtesy of Dr. Lucille Georg via the Public Health Image Library of the Centers for Disease Control and Prevention.

Sporotrichosis
Sporotrichosis

This photo shows cutaneous nodules in a lymphangitic (sporotrichoid) distribution over the dorsum of the right hand.

Image courtesy of Karen McKoy, MD.

Lymphocutaneous sporotrichosis is chronic and indolent; it is potentially fatal only if bacterial superinfections cause sepsis.

Rarely, in patients without primary lymphocutaneous lesions, hematogenous spread leads to indolent infections of multiple peripheral joints, sometimes bones, and, less often, genitals, liver, spleen, kidneys, or meninges. These infections are more common among patients with immunocompromise due to another disorder (eg, alcohol use disorder). Equally rare is chronic pneumonia caused by inhaling spores and manifested by localized infiltrates or cavities, most often in patients with preexisting chronic lung disease.

Diagnosis of Sporotrichosis

  • Clinical evaluation

  • Culture

The diagnosis of sporotrichosis is suspected based on clinical presentation in a patient with a history of possible exposure to the fungus (eg, gardener, landscaper, forester).

The characteristic nodular lymphangitis/cutaneous clinical presentation of sporotrichosis can also be caused by other pathogens, including Mycobacterium tuberculosis, atypical mycobacteria, Nocardia, Francisella tularensis, and Leishmania brasiliensis. Microbiologic diagnosis can usually be made when appropriate histologic stains and cultures of biopsied tissues are obtained (1). During the early, nondisseminated stage, the primary lesion is sometimes misdiagnosed as a spider bite.

Culture of tissue from the active infection site provides the definitive diagnosis. S. schenckii yeasts can be seen only rarely in fixed-tissue specimens, even with special staining. Serologic tests are not available.

Diagnosis reference

  1. 1. Tobin EH, Jih WW: Sporotrichoid lymphocutaneous infections: Etiology, diagnosis and therapy. Am Fam Physician 63(2):326–332, 2001.

Treatment of Sporotrichosis

  • Itraconazole

itraconazole

More Information

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

  1. Centers for Disease Control and Prevention (CDC): Sporotrichosis: Information about sporotrichosis, including risk and prevention

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