Mupirocin

Mupirocin inhibits bacterial RNA and protein synthesis. It is available only as a 2% topical preparation, which is bactericidal against Mupirocin inhibits bacterial RNA and protein synthesis. It is available only as a 2% topical preparation, which is bactericidal againststaphylococci and beta-hemolytic streptococci. Systemic absorption of topical mupirocin is negligible.

Mupirocin is used for

• Impetigo

• Minor superficial secondarily infected skin lesions

• Eradication of Staphylococcus aureus nasal carriage, although relapse rates may be high

Chronic therapy leads to mupirocin-resistant staphylococci.

Mupirocin is nontoxic but, when applied to denuded skin or mucous membranes, may cause itching and burning.Mupirocin is nontoxic but, when applied to denuded skin or mucous membranes, may cause itching and burning.