Hyponatremia Correction Infusate Rate

 

Input
 

Serum Na Change Per Hr		mEq/L/hr
Serum Na		mEq/L
Water Fract	Child (0.6)
	Adult Female (0.5)
	Elderly Female (0.45)
	Adult Male (0.6)
	Elderly Male (0.5)
Weight		gm kg lb mg
IV Na	5% NaCl (855)
	3% NaCl (513)
	0.9% NaCl (Normal Saline) (154)
	Ringer Lactate (Includes 4 mEq/L K+) (134)
IV K		mEq/L

 

Results
 

Infusate Rate		L/min L/sec mL/hr mL/min mL/sec
Serum Na Change Per Liter		mEq/L
Decimal Precision   0 1 2 3

 

 

Notes

• The default unit of measure for weight is kilograms. Please verify that the correct unit of measure has been selected.
• OVERLY RAPID CORRECTION OF HYPONATREMIA MAY CAUSE CEREBRAL EDEMA AND OSMOTIC DEMYELINATION WHICH CAN RESULT IN BRAIN DAMAGE OR DEATH.
• The serum Sodium should generally be corrected at a rate that does not exceed 8 mEq/L/day. Remaining within this target, the initial rate of correction can still be 1-2 mEq/L/hr for several hours in patients with severe symptoms.
• In milder cases, fluid restriction alone (800-1200 mL/day) is usually adequate to correct the serum sodium.
• Hypokalemia can aggravate the cerebral effects of hyponatremia and should be corrected.

 
Equations used
 

InfusateRate = (1000 * SerumNaChangePerHr * ((WaterFract * Weight) + 1)) / (IVNa + IVK - SerumNa)

SerumNaChangePerLiter = (IVNa + IVK - SerumNa) / ((WaterFract * Weight) + 1)

 

 

Calculation Details and Variables

• Equation parameters such as Water Fract, have two or more discrete values that may be used in the calculation. The numbers in the parentheses, e.g. (0.6), represent the values that will be used.

 

References

1. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581-89. PubMed ID: 10824078