Hepatitis Discriminant Function for Corticosteroid Therapy in Alcoholic Hepatitis

 

Input
 

Prothrombin Time		hr min sec
Control Prothrombin Time		hr min sec
Bilirubin		mcmol/L mg% mg/dL

 

Result
 

Index

 

 

Notes

• Patients with a score ≥32 may benefit from treatment with corticosteroids.

 
Equations used
 

Index = 4.6 * (ProthrombinTime - ControlProthrombinTime) + Bilirubin

 

 

References

1. Carithers RL Jr, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, Maddrey WC. Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. Ann Intern Med. 1989 May 1;110(9):685-90. PubMed ID: 2648927
2. Maddrey WC, Boitnott JK, Bedine MS, et.al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978 Aug;75(2):193-9. PubMed ID: 352788
3. Ramond MJ, Poynard T, Rueff B, Mathurin P, Theodore C, Chaput JC, Benhamou JP. A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med. 1992 Feb 20;326(8):507-512. PubMed ID: 1531090
4. Scott L. Friedman, MD et. al. editors. Current Diagnosis & Treatment in Gastroenterology. 2nd Ed. (2003). NLMN ID: 101156628