Sex
		Female (2 points)
		Male (0 points)
Alkaline phosphatase / aminotransferase ratio
		>3.0 (-2 points)
		<3.0 (2 points)
Ratio of serum globulin, gamma globulin or IgG to corresponding normal
		>2.0 (3 points)
		1.5 - 2.0 (2 points)
		1.0 - 1.5 (1 point)
		<1.0 (0 points)
Autoantibodies (titres by immunofluorescence on rodent tissues)
		ANA or LKM-1 >1:80 (>1:20 child) (3 points)
		ANA or LKM-1 1:80 (1:10 - 1:20 child) (2 points)
		ANA or LKM-1 1:40 (1 point)
		ANA or LKM-1 <1:40 (<1:10 child) (0 points)
		SMA >1:80 (>1:20 in child) (3 points)
		SMA 1:80 (1:20 child) (2 points)
		SMA 1:40 (1 point)
		SMA <1:40 (<1:20 child) (0 points)
		Positive SLA, ASGP-R, LSP, LC1, LP, HHPM or sulfatide (2 points)
		Positive antimitochondrial antibody (-2 points)
Viral markers
		IgM anti-HAV, HBsAg or IgM anti HBc (-3 points)
		Anti-HCV by ELISA or RIBA (-2 points)
		Anti-HCV by PCR / RNA (-3 points)
		Other test or active viral infection (-3 points)
		Sero negative for virii (3 points)
History of recent hepatotoxic drug exposure or parenteral exposure to blood products
		Yes (-2 points)
		No (1 point)
Alcohol consumption
		Male <35 gm/day; female <25 gm/day (2 points)
		Male 35-35 gm/day; female 25-40 gm/day (0 points)
		Male 50-80 gm/day; female 40-60 gm/day (-2 points)
		Male >80 gm/day; female >60 gm/day (-1 point)
Genetic factors
		Other autoimmune diseases in patient or first-degree relatives (1 point)
		HLA B8-DR3 haplotype or DR4 allotype (1 point)
Histology
		CAH / piecemeal necrosis / lobular involvement / bridging necrosis (3 points)
		Same without lobular involvement or bridging (2 points)
		Rosetting (1 point)
		Marked plasma cell infiltrate (1 point)
		Biliary changes (-1 point)
		Granuloma / siderosis / copper / other changes suggestive of a different etiology (-3 points)
Response to therapy
		Complete response (2 points)
		Partial response or failure (0 points)
		No response in terms of disease activity (-2 points)
		Relapse during or after treatment withdrawl after complete initial response (3 points)

Total Criteria Point Count:
 

 

16 to 25 Points:	Definite Autoimmune Hepatitis
10 to 15 Points:	Probable AIH
0 to 9 Points:	Less likely AIH

 

 

18 to 25 Points:	Definite Autoimmune Hepatitis
12 to 17 Points:	Probable AIH
0 to 11 Points:	Less likely AIH