Hereditary periodic fever syndromes are hereditary disorders that periodically cause episodes of fever and other symptoms that are not due to usual childhood infections or any other obvious disorder.
The most common hereditary periodic fever syndrome across all age groups is
A similar disorder that causes episodes of fever but is not thought to be hereditary is
PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis)
Other less common syndromes include the following:
Anakinra
PAPA syndrome (pyogenic arthritis, pyoderma gangrenosumAcne
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Symptoms of hereditary periodic fever syndromes usually begin during childhood. Fewer than 10% of people develop symptoms after age 18. People periodically have attacks of fever and inflammation but feel well between attacks.
